"Ko te Baking Soda (Sodium Bicarbonate) kāore i te paitini, kāore hoki he kino, kua whakakīia ki roto i tētahi nano 'capsule' haumaru (liposome), ā, ko te tetracycline me te kaha here wheua ka whakanohoia ki runga i te mata hei mimiti ki te mata o te wheua. Ina whakangaromia e ngā osteoclasts te kiko wheua mā te whakaputa waikawa, ka taea e rātou te tuku tonu i te Sodium Bicarbonate, ka aukati i te mahi a ngā osteoclasts me te whakatutuki i te whāinga o te aukati i te osteoporosis." Nō nā tata nei i whakaputahia ai ā rātou kitenga e tētahi rōpū i arahina e Ahorangi Shunwu Fan o te Tari Orthopedics, Run Run Shaw Hospital, Zhejiang University, me Ahorangi Ruikang Tang o te Tari Matū, Zhejiang University, i roto i te Journal of the American Chemical Society.
E ai ki te kupu whakataki, he rite ngā osteoclasts ki ngā moko i roto i te rākau, i te wā kotahi e kaha ana, tae atu ki te rākau teitei, engari nā te pirau me te hinganga mō te wā roa. E whakapono ana ngā rangahau o nāianei ko te tino take o te osteoporosis ko te whakahohenga koretake o ngā osteoclasts, ā, ko te whakaputanga waikawa e ngā osteoclasts e kiia ana ko te take tuatahi matua o te whakangaromanga o te wheua e ngā osteoclasts me te whakaritenga e tika ana mō tā rātou whakahoro i te kiko wheua.
Ko ngā rongoā matua i roto i te rongoā haumanu mō te osteoporosis e tutuki ai te kaupapa o te ārai i te mimiti wheua me te whakatairanga i te anabolism wheua mā te arotahi ki te whakahaere i te koiora osteoclast, osteoblast rānei, engari kāore e patu i te taahiraa tuatahi matua o te taiao waikawa o waho o te hanganga osteoclast mai i te pūtake. Nō reira, ka taea e ngā rongoā o nāianei te whakaroa i te ngaronga wheua i roto i te hunga kaumātua ki tētahi taumata, engari he maha ngā wā kāore e taea te whakakore katoa i te whakangaromanga wheua kua puta, ā, ko te whakahaere whiriwhiri i ngā rongoā kore-wheua ka arahi hoki ki ngā pānga taha kore-whaitake me ētahi atu pānga paitini o ngā whekau.
Hei tāpiritanga, ahakoa ko ngā osteoclasts te take o te osteoporosis, he maha ngā rangahau kua whakaatu he mahi tā rātou ki te whakatairanga i te hanganga wheua me te angiogenesis hei "pūtau mua" i mua i te whakaputa waikawa. Nō reira, he mea tino nui te aukati tika i ngā osteoclasts.
Nā te tīma a Fan Shunwu me te tīma a Tang Ruikang i ārahi te arotahi o ngā liposome Sodium Bicarbonate ki te mata o te wheua, kia hangaia ai he paparanga tiaki kawakore, kia whakakorea ai te waikawa e tukuna ana e ngā osteoclasts, kia aukati i te whakahohenga rerekē o ngā osteoclasts, me te hanga anō i te taurite o te taiao moroiti wheua kia tutuki ai te pānga o te rongoā i te osteoporosis.
I kī a Lin Xianfeng, he taote wheua i te Hōhipera Run Run Shaw o Te Whare Wānanga o Zhejiang, i kitea i roto i te rangahau he nui te apoptosis o ngā osteoclast nā ngā rauemi liposome kawakore me te taiao waikawa o ngā osteoclast, ā, i tukuna atu hoki he maha o ngā vesicle waho o te pūtau. "He rite ki te huinga domino, e panaia ana i ia paparanga, ka whakanuia i ia taahiraa kia tino ātete ki te whakangaromanga o te wheua i puta mai i te kaha o ngā osteoclast."
Wā tuku: Hanuere-27-2021